BSJ-04-122

SKU: orb1744374

Description

BSJ-04-122 is a potent, covalent dual inhibitor of MKK4 (IC50=4 nM) and MKK7 (IC50=181 nM). This small molecule is a valuable research tool for investigating JNK pathway signaling in cancer, with utility in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2513289-74-0
• MW: 313.74
• Purity: 98.09% (May vary between batches)
• Formula: C₁₅H₁₂ClN₅O
• SMILES: N(C1=C2C(NC=C2Cl)=NC=N1)C3=C(NC(C=C)=O)C=CC=C3
• Target: p38 MAPK,JNK
• Solubility: DMSO:16.6 mg/mL (52.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.94 mM)

Bioactivity

• Target IC50:
  MKK7:181 nM|MKK4:4 nM
• In Vitro:
  BSJ-04-122 has inhibitory activity against MKK4 and MKK7 with IC50 values of 4 nM and 181 nM respectively. BSJ-04-122 (1, 5, 10 μM; 6 h) induces a strong reduction in JNK phosphorylation. BSJ-04-122 (0, 1.25, 2.5, 5, 10, 20 μM; 72 h) showed enhanced antiproliferative effects when combined with JNK-IN-8.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MKK4

Compound Identifiers

PubChem CID

166642484