Bromosporine

SKU: orb1300932

Description

Bromosporine is a potent, broad-spectrum bromodomain inhibitor with high affinity for BRD2, BRD4, BRD9, and CECR2. It is widely used in biochemical and cellular research to investigate epigenetic mechanisms in oncology, inflammation, and other disease models, facilitating both in vitro and in vivo studies.

Research Area

Epigenetics & Chromatin, Neuroscience

Key Properties

• CAS Number: 1619994-69-2
• MW: 404.44
• Purity: >98%
• Formula: C₁₇H₂₀N₆O₄S
• SMILES: CCOC(=O)Nc1cc(nn2c(C)nnc12)-c1ccc(C)c(NS(C)(=O)=O)c1
• Target: Bromodomain
• Solubility: Soluble in DMSO (up to 25 mg/ml)

Bioactivity

• Target IC50:
  BRD9:0.122 μM|CECR2:0.017 μM|BRD4:0.29 μM|BRD2:0.41 μM
• In Vitro:
  Bromosporine (1 μM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 μM. Bromosporine (18 μM) has moderate cytotoxicity in HeLa cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T cells, AIDS, Bromosporine, Apoptosis, anticancer, antitumor, AML, Cyclin dependent kinase, CDK, CECR2, BRD4, BRD2, BRD9, colorectal cancer, EpigeneticReaderDomain, Epigenetic Reader Domain, HIV, Inhibitor, HCT116, HT29, Human immunodeficiency virus, KASUMI-1, inhibit, MV4;11

Compound Identifiers

PubChem CID

72943187