Bromocriptine mesylate

SKU: orb1301440

Description

Bromocriptine mesylate (CB-154) is a potent and selective D2 dopamine receptor agonist, exhibiting high binding affinity (Ki = 2.5 nM). It is widely used in research for studying dopaminergic pathways, prolactin secretion, and Parkinson's disease models in both in vitro and in vivo experimental systems.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 22260-51-1
• MW: 750.7
• Purity: 99.96% (May vary between batches)
• Formula: C₃₃H₄₄BrN₅O₈S
• SMILES: CS(O)(=O)=O.[H][C@@]12CCCN1C(=O)[C@H](CC(C)C)N1C(=O)[C@](NC(=O)[C@H]3CN(C)C4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]21O)C(C)C
• Target: Autophagy,Dopamine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.66 mM);DMSO:50 mg/mL (66.6 mM)

Bioactivity

• Target IC50:
  D2:2.5 nM(ki)
• In Vitro:
  The ergot alkaloid bromocriptine (BKT) was found to act as a strong inhibitor of purified neuronal nitric oxide synthase (NOS) (IC50 = 10 +/- 2 microM) whereas it was poorly active towards inducible macrophage NOS (IC50 > 100 microM). BKT affects the activation of NOS by calmodulin, as it not only inhibits L-arginine oxidation to NO and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by neuronal NOS. These results suggest that BKT could exert some of its therapeutic effects by interfering with the NOS-dependent formation of nitric oxide and/or superoxide ion in various tissues.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Bromocriptine, Bromocriptine Mesylate, Bromocriptine mesylate, D2, DopamineReceptor, Dopamine Receptor, Dopamine, CB154, CB-154, CB 154, inhibit, Inhibitor

Compound Identifiers

PubChem CID

5284352