Britannin

SKU: orb1301484

Description

Britannin

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 33627-28-0
• MW: 366.41
• Purity: 99.98%
• Formula: C₁₉H₂₆O₇
• SMILES: [H][C@]12C[C@@H](C)[C@]3([H])[C@H](C[C@H](O)[C@@]3(C)[C@@H](OC(C)=O)[C@]1([H])C(=C)C(=O)O2)OC(C)=O
• Target: Pyroptosis,AMPK,NOD-like Receptor (NLR),Apoptosis,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.46 mM);DMSO:45 mg/mL (122.81 mM)

Bioactivity

• Target IC50:
  NLRP3:3.630 μM
• In Vitro:
  Britannin, a sesquiterpene lactone isolated from Asteraceae family, has antiproliferative activity on the MCF-7 and MDA-MB-468 human breast cancer cells. Annexin V/propidium iodide (PI) staining, Hoechst 33258 staining, and caspase-3/9 activity assay confirmed that britannin is able to induce apoptosis in MCF-7 and MDA-MB-468 cells. The expression of Bcl-2 was noticeably decreased in response to britannin treatment, while the expression of Bax protein was increased, which were positively correlated with elevated expression of p53. Moreover, britannin also increased reactive oxygen species (ROS) generation which in turn triggered the loss of mitochondrial transmembrane potential (ΔΨm) and the subsequent release of cytochrome c from mitochondria into cytosol.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, autophagy, Autophagy, Apoptosis, Apoptosis inducer, Britannin

Compound Identifiers

PubChem CID

14466541