Briciclib

SKU: orb1221716

Description

Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.(In Vitro):Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.

Key Properties

• CAS Number: 865783-99-9
• MW: 474.42
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₃O₁₀PS
• SMILES: c1(cc(c(c(c1)OC)/C=C/S(=O)(=O)Cc1ccc(c(c1)OP(=O)(O)O)OC)OC)OC
• Target: Microtubule/Tubulin
• Solubility: DMSO : ≥ 31 mg/mL; 65.34 mM

Bioactivity

• In Vitro:
  Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ON 014185

Quick Database Links

Gene Symbol

Microtubule/Tubulin