Brevilin A

SKU: orb1302666

Description

Brevilin A

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 16503-32-5
• MW: 346.42
• Purity: 99.97%
• Formula: C₂₀H₂₆O₅
• SMILES: [H][C@@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](OC(=O)C(\C)=C/C)[C@]1([H])[C@H](C)C(=O)O2
• Target: Apoptosis,Autophagy,Anti-infection,JAK,STAT
• Solubility: DMSO:100 mg/mL (288.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.43 mM)

Bioactivity

• Target IC50:
  STAT3 signaling:10.6 µM (IC50)
• In Vitro:
  In vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima. The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifection, Anti-infection, Antiinfection, Autophagy, Apoptosis, Brevilin A, Inhibitor, Janus kinase, JAK, inhibit, STAT

Compound Identifiers

PubChem CID

12302076