Breceptin

SKU: orb3180501

Description

Breceptin (B 9870) serves as an antagonist and partial agonist for bradykinin B1/B2 receptors (B1/B2R). In rabbit jugular vein contraction assays, it functions as an irreversible B2R antagonist, inhibiting bradykinin-induced vasoconstriction. B-9870 exhibits partial agonist characteristics in HEK 293 cells with high rabbit B2R expression, activating ERK1/2 phosphorylation, calcium mobilization, arachidonic acid release, and receptor internalization. Breceptin is applicable in research on breast cancer and non-small cell lung cancer inhibition.

Key Properties

• Target: Bradykinin Receptor,ERK
• CAS Number: 215713-39-6
• MW: 2815.33
• Formula: C₁₃₆H₂₀₀N₃₈O₂₈
• SMILES: C([C@H](NC([C@@H](NC([C@@H](NC(CNC(=O)[C@H]1N(C(=O)[C@H]2N(C([C@@H](NC([C@H](NC(CCCCCCC(N[C@@H](C(N[C@H](C(=O)N3[C@H](C(=O)N4[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](C(=O)N5[C@@]6([C@](C[C@H]5C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)(CCCC6)[H])[H])[C@@H]7CC=8C(C7)=CC=CC8)=O)CO)=O)C9CC=%10C(C9)=CC=CC%10)=O)=O)C[C@@H](O)C4)CCC3)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC2)C[C@H](O)C1)=O)[C@H]%11CC=%12C(C%11)=CC=CC%12)=O)CO)=O)C%13CC=%14C(C%13)=CC=CC%14)(=O)N%15[C@@]%16([C@](C[C@H]%15C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)(CCCC%16)[H])[H]

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bradykinin Receptor,ERK