BRD8518

SKU: orb2665233

Description

BRD8518 is a potent small molecule PCSK9 inhibitor (EC50=0.23 µM) used in cardiovascular research. It functions by upregulating LDL receptor expression to enhance LDL uptake, thereby lowering lipid levels in experimental models for atherosclerosis and hypercholesterolemia studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1565828-01-4
• MW: 607.62
• Formula: C₃₃H₃₂F₃N₃O₅
• SMILES: O=C1C=2C(OC[C@]3([C@@](N1C)(CC[C@@H](CC(NC4CC=5C(C4)=CC=CC5)=O)O3)[H])[H])=CC=C(NC(=O)C6=CC=C(C(F)(F)F)C=C6)C2
• Target: LDLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

73819568