BRD7586

SKU: orb1744165

Description

BRD7586 is a cell-permeable small molecule that acts as a selective inhibitor of Streptococcus pyogenes Cas9 (SpCas9), improving its specificity by reducing off-target editing. Its application in both in vitro and in vivo CRISPR-Cas9 genome editing experiments helps enhance the precision of genetic modifications for research purposes.

Research Area

Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 895460-70-5
• MW: 407.89
• Purity: 97.70% (May vary between batches)
• Formula: C₁₇H₁₄ClN₃O₃S₂
• SMILES: O=C(NC1=NC(=CS1)C=2C=CN=CC2)CCS(=O)(=O)C3=CC=C(Cl)C=C3
• Target: CRISPR/Cas9,Antibacterial
• Solubility: DMSO:8 mg/mL (19.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.45 mM)

Bioactivity

• In Vitro:
  BRD7586 specifically binds to SpCas9 but not Cas12a in cells. In the HiBiT-knock-in assay, 0-20 μM BRD7586 inhibited SpCas9 in a dose-dependent manner.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cas9, BRD 7586, CRISPR, CRISPR/Cas9

Compound Identifiers

PubChem CID

22581367