BRD7389

SKU: orb1308523

Description

BRD7389 is a potent small molecule inhibitor of the RSK kinase family, demonstrating IC50 values of 1.5 μM (RSK1), 2.4 μM (RSK2), and 1.2 μM (RSK3). It is a valuable research tool for investigating RSK signaling in cancer cell proliferation and survival, with utility in both in vitro and in vivo experimental models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 376382-11-5
• MW: 366.41
• Purity: 99.51% (May vary between batches)
• Formula: C₂₄H₁₈N₂O₂
• SMILES: O=C1c2ccccc2-c2c(NCCc3ccccc3)c(=O)[nH]c3cccc1c23
• Target: SGK,Pim,FLT,S6 Kinase,CDK,DAPK
• Solubility: DMSO:20 mg/mL (54.58 mM)

Bioactivity

• Target IC50:
  RSK1:1.5 μM|SGK:13.8 μM|RSK2:2.4 μM|DRAK1:2.8 μM|PKG1α:6.5 μM|Pim1:3.7 μM|CDK5-p35:6.5 μM|RSK3:1.2 μM|FLT3:3.5 μM
• In Vitro:
  BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diabetes, DRAK1, CDK5/p35, colon, BRD7389, BRD-7389, BRD 7389, cancer, FLT3, Inhibitor, pancreatic, islets, inhibit, RSK, RSK2, RSK3, RSK1, S6 Kinase, S6K, S6Kinase, Ribosomal S6 Kinase (RSK), SNU-407, PIM1, Pim1, PKG1α, SGK

Compound Identifiers

PubChem CID

1080352