BRD5648

SKU: orb1309903

Description

BRD0705 is a paracrine-selective, orally bioavailable GSK3α inhibitor with a Kd of 4.8 μM and an IC50 of 66 nM, exhibiting 8-fold selectivity over GSK3β. It serves as a research tool for studying acute myeloid leukemia, with applications in both in vitro and in vivo experimental models. BRD5648 functions as its corresponding negative control compound.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2056261-42-6
• MW: 321.42
• Purity: 99.89% (May vary between batches)
• Formula: C₂₀H₂₃N₃O
• SMILES: CC[C@]1(C2=CNNC2=NC2=C1C(=O)CC(C)(C)C2)c1ccccc1
• Target: GSK-3
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.56 mM);DMSO:300 mg/mL (933.36 mM)

Bioactivity

• In Vitro:
  BRD5648 does not induce changes in enzyme phosphorylation or total β-catenin protein stabilization.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

compound, BRD0705, BRD-0705, BRD 5648, BRD 0705, BRD5648, BRD-5648, control, (R)-enantiomer, (R)-BRD0705, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK3, GSK-3, GSK-3α, inhibit, negative

Compound Identifiers

PubChem CID

136980414