BRD1172

SKU: orb3173570

Description

BRD1172 (ML320) is a selective inhibitor of GSK3β, exhibiting an IC50 of 24 nM, demonstrating greater potency against GSK3β compared to CDK5. It significantly inhibits GSK3β-mediated Tau phosphorylation in SH-SY5Y cells and reduces the negative regulation by GSK3β on β-catenin degradation and TCF/LEF promoter activity. BRD1172 is applicable in research on Alzheimer's disease, cardiac hypertrophy, and cancer.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1597438-86-2
• MW: 391.39
• Formula: C₂₀H₂₀F₃N₃O₂
• SMILES: C(F)(F)(F)C1=C2[C@@H](C3=C(NC2=NN1)CC(C)(C)CC3=O)C4=C(OC)C=CC=C4
• Target: GSK-3,Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GSK-3,Wnt/beta-catenin