Brassinin

SKU: orb1302910

Description

Brassinin is a phytoalexin derived from Brassica campestris with documented chemopreventive properties. It demonstrates antiproliferative and pro-apoptotic effects in various cancer cell lines in vitro and has shown chemopreventive efficacy in murine models of skin carcinogenesis in vivo.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 105748-59-2
• MW: 236.36
• Purity: 98.25% (May vary between batches)
• Formula: C₁₁H₁₂N₂S₂
• SMILES: CSC(=S)NCc1c[nH]c2ccccc12
• Target: Antifungal,Endogenous Metabolite
• Solubility: DMSO:55 mg/mL (232.7 mM)

Bioactivity

• In Vivo:
  Brassinin attenuates tumor growth in a xenograft lung cancer mouse model through modulation of E3 SUMO-protein ligase 3 (PIAS-3) and suppressor of cytokine signaling-3 (SOCS-3).
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• In Vitro:
  In lung cancer cells, brassinin inhibits constitutive and IL-6-inducible STAT3 signaling through modulation of PIAS-3 and SOCS-3.It appears that brassinin induces apoptosis in PC-3 prostate cancer cells via the suppression of PI3K/Akt/mTOR/S6K1 signaling.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antifungal, Brassinin, Brassinine, BSN, inhibit, Inhibitor

Compound Identifiers

PubChem CID

3035211