Branaplam

SKU: orb1302690

Description

Branaplam

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1562338-42-4
• MW: 393.48
• Purity: 98.93%
• Formula: C₂₂H₂₇N₅O₂
• SMILES: CC1(C)CC(CC(C)(C)N1)Oc1ccc(nn1)-c1ccc(cc1O)-c1cn[nH]c1
• Target: Potassium Channel,DNA/RNA Synthesis
• Solubility: DMSO:3.96 mg/mL (10.06 mM)

Bioactivity

• Target IC50:
  ERG (human):6.3 μM (EC50)|SMN:20 nM (IC50)
• In Vivo:
  To evaluate the efficacy of NVS-SM1, we used the SMNΔ7 mouse model, which displays a severe phenotype. In the specific colony used for this study, death typically occurs before postnatal day 15. We were pleased to observe that, in addition to a dose-dependent elevation of SMN protein in the brain, oral administration of NVS-SM1 improved body weight and extended lifespan, with 50% of the animals in the 1 mg per kg body weight group and 62% of animals in the 3 mg per kg body weight group showing increased survival.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium Channel, PotassiumChannel, RNA Synthesis, RNASynthesis, SMN2, SMN, SMA, splicing, spinal, survival, Inhibitor, LMI070, LMI-070, LMI 070, KcsA, motor, inhibit, muscular, orally, NVS-SM1, neuron-2, gene, hERG, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, Branaplam, atrophy

Compound Identifiers

PubChem CID

135565042