Bradanicline tosylate

SKU: orb3210656

Description

Bradanicline (TC-5619) tosylate is an oral agonist of the α7nAChR with moderate penetration of the blood-brain barrier. It demonstrates high affinity and subtype selectivity for the human α7nAChR. This compound exhibits antitussive activity, dependent on sustained receptor binding and activation. Systemic administration of Bradanicline tosylate enables dose-dependent inhibition of cough induced by citric acid, bradykinin, and inhaled nicotine. In preclinical studies, Bradanicline tosylate has shown good tolerance and is commonly used in research related to chronic refractory cough.

Key Properties

• CAS Number: 1111942-11-0
• MW: 533.64
• Formula: C₂₉H₃₁N₃O₅S
• SMILES: S(=O)(=O)(O)C1=CC=C(C)C=C1.C([C@H]1[C@H](NC(=O)C2=CC=3C(O2)=CC=CC3)C4CCN1CC4)C=5C=CC=NC5
• Target: AChR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR