Bractoppin

SKU: orb1298563

Description

Bractoppin is a potent and selective small-molecule inhibitor of the human BRCA1 tBRCT domain, disrupting phosphopeptide binding with nanomolar IC₅₀. Its unique engagement of a hydrophobic pocket confers selectivity, making it a valuable chemical probe for studying BRCA1 function in DNA damage repair pathways in cellular and biochemical assays.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2290527-07-8
• MW: 414.47
• Purity: 99.65% (May vary between batches)
• Formula: C₂₅H₂₃FN₄O
• SMILES: Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.96 mM);DMSO:83.3 mg/mL (200.98 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bractoppin, BRCA1 tBRCT, DNA break, DNA damage, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, G2 arrest, Inhibitor, inhibit, RNASynthesis, RNA Synthesis, RAD51, phosphopeptide

Compound Identifiers

PubChem CID

137519541