BpV(HOpic)

SKU: orb1299354

Description

BpV(HOpic) is a highly potent and selective PTEN inhibitor with an IC50 of 14 nM. This small molecule is widely used in biochemical and cellular research to modulate the PI3K/AKT signaling pathway, facilitating studies in oncology, neurobiology, and metabolic diseases both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 722494-26-0
• MW: 347.24
• Purity: 99.86%
• Formula: C₆H₄K₂NO₈V
• SMILES: O=C1[O-][V+3]23([O-][O-]2)([O-][O-]3)([N]4=CC(O)=CC=C14)=O.[K+].[K+]
• Target: PTEN
• Solubility: H2O:58.75 mg/mL (169.19 mM);DMSO:Insoluble

Bioactivity

• Target IC50:
  PTEN:14 nM(Cell-free assay)
• In Vitro:
  1 μM BpV(Hopic) is capable of enhancing the migration of C2C12 myoblasts by approximately 40 % in the presence of myotube conditioned media, without significantly affecting their capacity to differentiate and fuse into multinucleated myotubes. Improved migration of myoblasts treated with 1 μM BpV(Hopic) was associated with activation of PI3K/AKT and MAPK/ERK pathways, while their inhibition with either LY294002 or UO126, respectively, resulted in a reduction of C2C12 migration back to control levels

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bpV, bpV (HOpic), BpV(HOpic), HOpic, MAPK/ERK, MMAC1, inhibit, Inhibitor, PTEN, Phosphatase and tensin homolog, signalling, PI3K/AKT

Compound Identifiers

PubChem CID

176418227