BPR1M97

SKU: orb1710219

Description

BPR1M97 is a potent, brain-penetrant dual agonist of the mu opioid (MOP, Ki=1.8 nM) and nociceptin/orphanin FQ peptide (NOP, Ki=4.2 nM) receptors. This small molecule exhibits both antinociceptive and anti-injurious properties in preclinical research, making it a valuable tool for studying pain mechanisms and opioid-related neurobiology in vitro and in vivo.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2059904-66-2
• MW: 349.25
• Purity: 99.95% (May vary between batches)
• Formula: C₁₈H₁₈Cl₂N₂O
• SMILES: CN1CCc2ccccc2C1CNC(=O)c1ccc(Cl)c(Cl)c1
• Target: Opioid Receptor
• Solubility: DMSO:225 mg/mL (644.24 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.32 mM)

Bioactivity

• Target IC50:
  NOP:4.2 nM (ki)|MOP:1.8 nM (ki)
• In Vivo:
  In a murine model of cancer pain, BPR1M97 (1.8 mg/kg; s.c.; once) demonstrates antinociception.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BPR1M97, BPR-1M97, NOP, NOP receptor, MOP, Opioid Receptor, OpioidReceptor, μ-opioid receptor

Compound Identifiers

PubChem CID

137541784