BPR1K653

SKU: orb1738201

Description

BPR1K653 is a potent and selective Aurora-A/B kinase inhibitor with broad-spectrum anticancer activity in vitro, overcoming MDR1-mediated resistance. It induces endoreplication and apoptosis in cancer cells and demonstrates significant in vivo efficacy in xenograft models, including MDR1-positive tumors, supported by favorable pharmacokinetic profiles. This makes it a promising candidate for oncology research, particularly in studying drug-resistant malignancies.

Key Properties

• CAS Number: 1192754-07-6
• MW: 541.04
• Formula: C₃₀H₂₉ClN₆O₂
• SMILES: Cl.CN(C)Cc1ccccc1NC(=O)Nc1ccc(CCNc2ncnc3oc(c(Cl)c23)-c2ccccc2)cc1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168440050