Bosutinib hydrate

SKU: orb1686162

Description

Bosutinib hydrate

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 918639-08-4
• MW: 548.46
• Purity: 99.87%
• Formula: C₂₆H₃₁Cl₂N₅O₄
• SMILES: O.COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
• Target: Src,Bcr-Abl
• Solubility: DMSO:80 mg/mL (145.86 mM)

Bioactivity

• Target IC50:
  Abl:2.4 nMol/L|Csk:314 nMol/L
• In Vivo:
  Administration of Bosutinib hydrate(SKI-606) at doses of 75 mg/kg twice daily or 150 mg/kg once daily can promote complete regression of human K562 xenografts for up to 40 day.
• In Vitro:
  Bosutinib hydrate(SKI-606)was a inhibitor of two Src-related kinases (i.e., Fgr and Lyn with IC50 of 0.174 and 0.850 nMol/L, respectively.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Bcr-Abl, BcrAbl, Src, SKI-606 hydrate, PF-05208763 hydrate, PF-5208763 hydrate

Compound Identifiers

PubChem CID

11990828