BOS-172722

SKU: orb1308530

Description

BOS-172722 is a potent and selective small molecule inhibitor of the MPS1 kinase, demonstrating an IC50 of 2 nM. It is a valuable chemical probe for studying the spindle assembly checkpoint in cancer research, with utility in both in vitro biochemical assays and in vivo xenograft models to investigate mitotic arrest and aneuploidy.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1578245-44-9
• MW: 446.55
• Purity: 99.79% (May vary between batches)
• Formula: C₂₄H₃₀N₈O
• SMILES: CCOc1cc(ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1)-c1nncn1C
• Target: Kinesin
• Solubility: 1M HCl:65 mg/mL (145.56 mM);DMSO:< 1.12 mg/mL

Bioactivity

• Target IC50:
  Mps1:2 nM
• In Vitro:
  BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM and it also has potential for the treatment of various forms of breast cancer.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast, autophosphorylation, cancer, BOS 172722, BOS172722, BOS-172722, inhibit, Inhibitor, Mps1, MPS1, Monopolar spindle 1

Compound Identifiers

PubChem CID

73386890