Bombesin acetate(31362-50-2 free base)

SKU: orb1296678

Description

Bombesin acetate is a 14-amino acid amphibian peptide homologous to mammalian neuromedin B and gastrin-releasing peptide. It is widely used in cancer research, particularly in studies of receptor signaling, tumor growth, and cell proliferation in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1222319-87-0
• MW: 1679.92
• Purity: 98.44% (May vary between batches)
• Formula: C₇₃H₁₁₄N₂₄O₂₀S
• SMILES: O=C(NC(C)C(NC(C(C)C)C(NCC(NC(C(NC(CC(C)C)C(NC(C(N)=O)CCSC)=O)=O)CC1=CN=CN1)=O)=O)=O)C(NC(C(CCC(N)=O)NC(C(CC(N)=O)NC(CNC(C(CC(C)C)NC(C(CCCNC(N)=N)NC(C(CCC(N)=O)NC(C(N2)CCC2=O)=O)=O)=O)=O)=O)=O)=O)CC3=CNC4=C3C=CC=C4.CC(O)=O
• Target: Bombesin Receptor
• Solubility: DMSO:5 mM

Bioactivity

• In Vitro:
  Bombesin is a tetradecapeptide with a COOH terminus ending in Gly-His-Leu-Met-NH2 and subsequently is shown to closely resemble two mammalian bombesin -related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB). Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is also found in mammalian brain, with its highest concentration in the hypothalamus. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor (IC50=1 nM).

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BombesinReceptor, Bombesin acetate(31362 50 2 free base), Bombesin acetate(31362502 free base), Bombesin acetate(31362-50-2 free base), Bombesin Receptor

Compound Identifiers

PubChem CID

155977590