BOLD-100 free base

SKU: orb1744839

Description

BOLD-100 (NKP-1339/IT-139) is a ruthenium-based compound that disrupts ER homeostasis by inhibiting stress-induced GRP78 upregulation. This action triggers ER stress and the UPR, perturbing the crosstalk between ER stress, lysosomes, and autophagy. It is used in cancer research, demonstrating antitumor activity in both in vitro and in vivo models.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 783324-98-1
• MW: 479.15
• Formula: C₁₄H₁₂Cl₄N₄Ru
• SMILES: [Cl-][Ru+4]([Cl-])([Cl-])([Cl-])([N]1=CC=2C=CC=CC2N1)[N]3=CC=4C=CC=CC4N3
• Target: HSP,Others,Autophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP,Others,Autophagy