Boc-NH-PEG12-NH2

SKU: orb1307494

Description

Boc-NH-PEG12-NH2 is a heterobifunctional PEG linker used in constructing PROTAC molecules for targeted protein degradation. Its extended, flexible spacer is crucial for facilitating ternary complex formation in both cellular and in vivo studies, enabling research across oncology and neurology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1642551-09-4
• MW: 688.84
• Purity: 99.52% (May vary between batches)
• Formula: C₃₁H₆₄N₂O₁₄
• SMILES: C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN)OCCNC(OC(C)(C)C)=O
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs comprise two ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other targets the specific protein. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, NHBoc-PEG12-amine, BocNHPEG12NH2, Boc-NH-PEG-12-NH2, Boc-NH-PEG12-NH2, Boc NH PEG12 NH2, PEGs, PROTAC Linker, PROTAC Linkers, PROTACLinker

Compound Identifiers

PubChem CID

137346699