BMY-27709

SKU: orb1700986

Description

BMY-27709

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 99390-76-8
• MW: 337.84
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₂₄ClN₃O₂
• SMILES: C[C@H]1N2[C@@](C[C@@H](NC(=O)C3=C(O)C=C(N)C(Cl)=C3)CC2)(CCC1)[H]
• Target: Influenza Virus
• Solubility: DMSO:50 mg/mL (148 mM)

Bioactivity

• In Vitro:
  BMY-27709 has an IC50 of 3-8 microM for a WSN 33 virus growth in a multicycle replication assay and is active against all H1 and H2 subtype viruses tested. However, BMY-27709 was found to be inactive against H3 subtype viruses, as well as influenza B/Lee/40 virus. BMY-27709 was also found to act against H1 and H2 viruses early in infection, suggesting that the target for inhibition is the hemagglutinin protein. This was confirmed through the use of reassortant viruses and the isolation of a virus resistant to BMY-27709. The resistant virus isolated contained phenylalanine to serine change at amino acid 110 of the HA2 subunit. That this single mutation was responsible for the acquisition of resistance to BMY-27709 was proven through reverse genetics, as a transfectant virus containing only this change was shown to be resistant to BMY-27709, while the control virus without this mutation remained sensitive. BMY-27709 is able to inhibit virus-induced red blood cell hemolysis, suggesting that it blocks the membrane fusion function of hemagglutinin. These experiments further illustrate that the hemagglutinin protein of the influenza virus is a viable target for the discovery and development of small-molecule inhibitors of virus growth.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

InfluenzaVirus, Influenza virus, Influenza Virus, BMY 27709, BMY27709, BMY-27709

Compound Identifiers

PubChem CID

127317