BMX-IN-1

SKU: orb1308543

Description

BMX-IN-1 is a potent and selective dual inhibitor of BMX and BTK kinases, with IC50 values of 8 nM and 10.4 nM, respectively. It demonstrates high selectivity, showing significantly reduced activity against Blk, JAK3, EGFR, Itk, and Tec. This inhibitor is a valuable chemical tool for studying TEC family kinase signaling in cancer and immunology research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1431525-23-3
• MW: 524.59
• Purity: ≥98% (May vary between batches)
• Formula: C₂₉H₂₄N₄O₄S
• SMILES: Cc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(NS(C)(=O)=O)cc1
• Target: BTK
• Solubility: DMSO:8 mg/mL (15.25 mM);DMF:9 mg/mL (17.16 mM)

Bioactivity

• Target IC50:
  BTK:10.4 nM|BMX kinase:8 nM
• In Vitro:
  BMX-IN-1 inhibits only wild-type BMX with an IC50 of 138 nM. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC50s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, BMX IN 1, BMX Kinase, BMX kinase inhibitor, Bruton tyrosine kinase, Btk, BTK, BMXIN1, BMX-IN-1, BMX, Bmx

Compound Identifiers

PubChem CID

71576693