BMT-145027

SKU: orb1309916

Description

BMT-145027 is a selective positive allosteric modulator (PAM) of the mGluR5 receptor, exhibiting an EC50 of 47 nM with no intrinsic agonist activity. This compound is a valuable research tool for investigating mGluR5 function in neurological disorders, facilitating both in vitro binding studies and in vivo behavioral models.

Research Area

Neuroscience

Key Properties

• CAS Number: 2018282-44-3
• MW: 438.83
• Purity: 99.62% (May vary between batches)
• Formula: C₂₃H₁₄ClF₃N₄
• SMILES: FC(F)(F)c1cc(ccc1Cl)-c1n[nH]c2nc(-c3ccccc3)c(C#N)c(C3CC3)c12
• Target: GluR
• Solubility: DMSO:2 mg/mL (4.56 mM)

Bioactivity

• Target IC50:
  mGluR5:47 nM
• In Vivo:
  BMT-145027 (30 mg/kg) leads to a significant increase in time spent with the novel object, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals(BMT-145027: 30 mg/kg) indicates a total plasma concentration of 2800 nM.
• In Vitro:
  BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM. BMT-145027 exhibits high MsLM stability (85% remaining) and a modest decrease in planarity (Fsp3 = 0.17).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Metabotropic glutamate receptors, mGluR, mGluR5, BMT145027, BMT-145027, BMT 145027

Compound Identifiers

PubChem CID

129012190