BMS493

SKU: orb1707523

Description

BMS493 is a pan-retinoic acid receptor (RAR) inverse agonist that suppresses RA-mediated differentiation and signaling by recruiting co-repressors. It is utilized in research to study retinoid pathways, including in models of development and toxicity, such as enhancing TPP-induced effects.

Research Area

Metabolism Research

Key Properties

• CAS Number: 215030-90-3
• MW: 404.5
• Purity: >99.99% (May vary between batches)
• Formula: C₂₉H₂₄O₂
• SMILES: CC1(C)CC=C(C#Cc2ccccc2)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
• Target: Phospholipase,Retinoid Receptor
• Solubility: DMSO:30 mg/mL (74.17 mM)

Bioactivity

• In Vivo:
  In contrast to freshly isolated ALDHhi cells, 6-day expansion with or without BMS 493 generated progeny that were unable to reduce hyperglycemia after iPan transplantation into STZ-treated NOD/SCID mice.
• In Vitro:
  Cells treated with BMS 493 (100 nM; 6 days) showed a twofold increase in the number of ALDHhi cells available for transplantation compared to untreated controls. Newly expanded ALDHhi cells exhibited increased numbers of CD34 and CD133-positive cells, along with a reduction in CD38 expression.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS 493, BMS493, BMS-493, RAR, phospholipase A2, Retinoid Receptor, RetinoidReceptor

Compound Identifiers

PubChem CID

9909190