BMS453

SKU: orb1704988

Description

BMS-189453 is a synthetic retinoid and potent RARβ-selective agonist. It acts as a testicular toxin and inhibits breast cell growth primarily by inducing active TGFβ. This compound is used in research fields such as oncology and toxicology for in vitro and in vivo studies of retinoid signaling and TGFβ-mediated growth inhibition.

Research Area

Metabolism Research

Key Properties

• CAS Number: 166977-43-1
• MW: 380.48
• Purity: 99.93% (May vary between batches)
• Formula: C₂₇H₂₄O₂
• SMILES: CC1(C)CC=C(c2ccccc2)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
• Target: Retinoid Receptor
• Solubility: DMSO:45 mg/mL (118.27 mM)

Bioactivity

• In Vitro:
  BMS453 (1 μM; 11 hours; 184 and HMEC cells) inhibits normal breast cell proliferation without significantly inducing apoptosis. The RARβ-selective agonist (BMS453) significantly reduces T47D breast cancer cell migration to levels comparable to RA inhibition, unlike RARα- or RARγ-selective agonists (BMS753 and BMS961), indicating RARβ's role in RA-inhibited cell migration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RAR/RXR, RARα, RARβ, RARγ, TGFβ, RetinoidReceptor, Retinoid Receptor, Retinoid X receptors, Retinoic acid receptors, retinoid, Inhibitor, inhibit, cell, breast, BMS 453, BMS 189453, BMS453, BMS-453, BMS189453, BMS-189453, arrest

Compound Identifiers

PubChem CID

9875424