BMS202 hydrochloride (1675203-84-5(free base))

SKU: orb1302643

Description

BMS202 hydrochloride (1675203-84-5 free base) is a potent small-molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 18 nM. It functions by binding to PD-L1, inducing its dimerization, and thereby blocking the immunosuppressive PD-1/PD-L1 pathway. This compound is a valuable tool for cancer immunotherapy research in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2089334-95-0
• MW: 455.97
• Purity: 99.47% (May vary between batches)
• Formula: C₂₅H₃₀ClN₃O₃
• SMILES: Cl.COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O
• Target: Apoptosis,PD-1/PD-L1
• Solubility: DMSO:30 mg/mL (65.79 mM)

Bioactivity

• Target IC50:
  PD-1/PD-L1:18 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PD-L1, PDL1, PD1, PD-1, PD1/PDL1, PD-1/PD-L1, PD-1/PD-L1 inhibitor 2 hydrochloride, PD-1/PD-L1 inhibitor 2 Hydrochloride, BMS202 hydrochloride (1675203 84 5(free base)), BMS202 hydrochloride (1675203845(free base)), BMS-202 hydrochloride (1675203-84-5(free base)), BMS202 hydrochloride (1675203-84-5(free base))

Compound Identifiers

PubChem CID

127263272