BMS-986397

SKU: orb2646005

Description

BMS-986397 is a cereblon-based molecular glue degrader targeting casein kinase 1α (CK1α). It induces rapid apoptosis and cell cycle arrest in TP53 wild-type acute myeloid leukemia (AML) cells, supporting its investigation in preclinical in vitro and in vivo models of AML.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2564486-44-6
• MW: 480.82
• Formula: C₂₁H₁₆ClF₃N₄O₄
• SMILES: O=C1N(CC=2C1=CC=C(C(N[C@@H]([C@@](F)(F)F)C3=C(Cl)C=CC=N3)=O)C2)[C@@H]4C(=O)NC(=O)CC4
• Target: Ligands for E3 Ligase,Molecular Glues,Casein Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155338753