BMS-986331

SKU: orb3210978

Description

BMS-986331 is an orally active, selective N-formyl peptide receptor 2 (FPR2) agonist, showing an EC50 of 0.5 nM in humans and 1 nM in rats. It activates signaling pathways including Gαi2, GαoA, Gα12, and Gα13, recruits β-arrestin1 and β-arrestin2, and inhibits downstream cAMP. Additionally, BMS-986331 induces the expression and release of the pro-resolving cytokine IL-10. It improves cardiac structure and function in a rat model of heart failure induced by permanent coronary artery occlusion. BMS-986331 is applicable in heart failure research.

Key Properties

• CAS Number: 2375684-52-7
• MW: 535.88
• Formula: C₂₅H₂₂ClF₃N₃O₃P
• SMILES: P(C)(C)(=O)C1=C(C=CC=C1)C2=C(F)C(F)=C(C=C2)N3C(=O)[C@H](NC(NC4=C(F)C=C(Cl)C=C4)=O)CC3
• Target: Arrestin,PKA,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Arrestin,PKA,Interleukin