BMS-986189

SKU: orb2563790

Description

BMS-986189 is a potent macrocyclic peptide inhibitor of PD-L1 with an IC50 of 1.03 nM. It is a valuable research tool for investigating cancer immunotherapy, suitable for both in vitro binding assays and in vivo model studies of immune checkpoint blockade.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• Target: PD-1/PD-L1
• CAS Number: 1629665-96-8
• MW: 1887.21
• Formula: C₉₁H₁₃₁N₂₁O₂₁S
• SMILES: C(C=1C=2C(N(CC(O)=O)C1)=CC=CC2)[C@H]3C(=O)N(C)[C@@H](CCCC)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(NCC(N)=O)=O)CSCC(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N5[C@](C(=O)N[C@@H](CN)C(=O)N[C@@H](CC(C)C)C(=O)N6[C@](C(=O)N[C@@H](CC=7C=8C(NC7)=CC=CC8)C(=O)N[C@@H](CCN)C(=O)N3)(C[C@@H](O)C6)[H])(CCC5)[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

124085715