BMS-986122

SKU: orb1305166

Description

BMS-986122 is a μ-opioid receptor positive allosteric modulator. In vitro, it potentiates endomorphin-1-stimulated β-arrestin recruitment in OPRM1-expressing cells with an EC50 of 3 µM. This compound is a research tool for studying biased signaling and allosteric modulation in opioid receptor pharmacology.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 313669-88-4
• MW: 448.78
• Purity: 98.42%
• Formula: C₁₆H₁₅BrClNO₃S₂
• SMILES: COc1ccc(cc1Br)C1SCCN1S(=O)(=O)c1ccc(Cl)cc1
• Target: Opioid Receptor
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (7.35 mM);DMSO:100 mg/mL (222.83 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

protein, positive, recruitment, β-arrestin, BMS 986122, BMS986122, BMS-986122, allosteric, adenylyl, cyclase, inhibit, Opioid Receptor, OpioidReceptor, modulator, Inhibitor

Compound Identifiers

PubChem CID

4644453