BMS-906024

SKU: orb1707530

Description

BMS-906024 (Osugacestat) is a potent, orally bioavailable γ-secretase inhibitor that blocks signaling from all four Notch receptors (Notch1-4). It demonstrates broad-spectrum antitumor activity in human cancer xenograft models, supporting its investigation in oncology research for both in vitro and in vivo studies.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1401066-79-2
• MW: 556.5
• Purity: 99.88%
• Formula: C₂₆H₂₆F₆N₄O₃
• SMILES: CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C1=O)c1ccccc1
• Target: Gamma-secretase
• Solubility: DMSO:5 mg/mL (8.98 mM)

Bioactivity

• Target IC50:
  Notch2:0.7 nM|Notch1:1.6 nM|Notch4:2.9 nM|Notch3:3.4 nM
• In Vitro:
  BMS-906024 (100 nM; 72 h) is an effective Notch activation inhibitor, which enhances the in vitro anti-tumor activity of paclitaxel.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Osugacestat, Notch2, Notch4, Notch3, Notch, Notch1, Gammasecretase, AL-101, BMS 906024, BMS906024, BMS-906024, BM-0018, γ secretase

Compound Identifiers

PubChem CID

66550890