BMS-813160

SKU: orb1302736

Description

BMS-813160 is a novel small molecule and the first dual antagonist of the CCR2 and CCR5 chemokine receptors to advance into clinical trials for cardiovascular indications. It serves as a key research tool for investigating the roles of these receptors in atherosclerosis and inflammation through in vitro binding assays and in vivo disease models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1286279-29-5
• MW: 484.64
• Purity: 99.66% (May vary between batches)
• Formula: C₂₅H₄₀N₈O₂
• SMILES: CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(nn23)C(C)(C)C)C1=O)NC(C)(C)C
• Target: CCR
• Solubility: DMSO:55 mg/mL (113.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.13 mM)

Bioactivity

• Target IC50:
  CCR2:6.2 nM|CCR5:3.6 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCR5, CC chemokine receptor, CD11b, dual antagonist, CTX, CCR, CCR2, BMS 813160, BMS813160, BMS-813160, mouse, inhibit, Inhibitor, inflammation, oral, peritonitis, thioglycollate

Compound Identifiers

PubChem CID

51039119