BMS-779788

SKU: orb1303495

Description

BMS-779788

Research Area

Metabolism Research

Key Properties

• CAS Number: 918348-67-1
• MW: 509.06
• Purity: 99.24%
• Formula: C₂₈H₂₉ClN₂O₃S
• SMILES: CC(C)(O)c1cn(c(n1)C(C)(C)c1ccccc1Cl)-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O
• Target: Liver X Receptor
• Solubility: DMSO:60 mg/mL (117.86 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (4.91 mM)

Bioactivity

• Target IC50:
  LXRβ:14 nM|LXRα:68nM
• In Vivo:
  BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist.
• In Vitro:
  BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EXEL 04286652, EXEL-04286652, EXEL04286652, Inhibitor, Liver X receptor, LiverXReceptor, Liver X Receptor, inhibit, LXRβ, LXR, LXRα, BMS779788, BMS-779788, BMS788, BMS-788, BMS 779788, BMS 788, XL652, XL-652, XL 652

Compound Identifiers

PubChem CID

59251511