BMS 753

SKU: orb1704895

Description

BMS 753 is a potent and selective RARα agonist with a Ki of 2 nM. This small molecule is a valuable research tool for studying retinoic acid receptor biology in vitro and has been utilized in research models investigating differentiation and oncogenesis.

Research Area

Metabolism Research

Key Properties

• CAS Number: 215307-86-1
• MW: 351.4
• Purity: 98.55% (May vary between batches)
• Formula: C₂₁H₂₁NO₄
• SMILES: CC1(C)C(=O)C(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
• Target: Retinoid Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.69 mM);DMSO:45 mg/mL (128.06 mM)

Bioactivity

• Target IC50:
  RARα:2 nM (Ki)
• In Vitro:
  In WT cells, BMS 753 can reduce RAR β Transcription level of 2 in a dose dependent mode. At RAR γ-/- cells, 100 nM of BMS 753 efficiently induces RAR β 2 Transcription. In contrast, in RAR α-/- In cells, up to 100 nM of BMS 753 can not activate RAR β 2.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS753, BMS-753, BMS 753, RARα, RetinoidReceptor, Retinoid Receptor

Compound Identifiers

PubChem CID

9884820