BMS-707035

SKU: orb1224125

Description

BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM.HIV Infection Phase 2 Discontinued.

Key Properties

• CAS Number: 729607-74-3
• MW: 410.42
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₉FN₄O₅S
• SMILES: Cn1c(=O)c(c(nc1N2CCCCS2(=O)=O)C(=O)NCc3ccc(cc3)F)O
• Target: HIV
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species. Pharmacokinetic Parameters of BMS-707035 in rat, dog and monkey (IV).
• In Vitro:
  BMS-707035 has antiviral activity with EC50 values of 2 nM and 17 nM in the presence of 10% FBS and 15 mg/mL human serum albumin, respectively. BMS-707035 has high plasma protein binding and not overtly cytotoxicy to several cell lines, with CC50 value of ≥45 μM. BMS-707035 has a relatively weak CYP inhibiton with IC50 value of ≥40 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS 707035 | BMS707035

Quick Database Links

Gene Symbol

HIV