BMS-599626 Hydrochloride

SKU: orb1689893

Description

BMS-599626 Hydrochloride

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 873837-23-1
• MW: 567.01
• Purity: 99.98%
• Formula: C₂₇H₂₈ClFN₈O₃
• SMILES: Cl.Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4n(Cc5cccc(F)c5)ncc4c3)c12
• Target: EGFR,HER
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.82 mM);DMSO:90 mg/mL (158.73 mM)

Bioactivity

• Target IC50:
  HER1:22 nM|HER4:190 nM|HER2:3 nM
• In Vivo:
  BMS-599626 hydrochloride given before and during irradiation improve the radioresponse of HN5 tumors in vivo
• In Vitro:
  BMS-599626 hydrochloride abrogates HER1 and HER2 signaling and inhibite the proliferation of tumor cell lines that are dependent on these receptors, with IC50 in the range of 0.24 to 1 μM.In GEO cells, HER1 phosphorylation is stimulated by treatment with EGF and is inhibited by BMS-599626 hydrochloride IC50 0. 75 μM).There is also nearly complete Inhibition of EGF-dependent MAPK (0. 8 μM) but only partial Inhibition of AKT signaling.The latter likely reflect the activation of AKT by multiple upstream signals.Treatment of N87 cells with BMS-599626 hydrochloride leads to the Inhibition of HER2 (0. 38 μM), which is expressed to a high level because of gene amplification, as well as MAPK and AKT phosphorylation (0.35 μM for both).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

HER4, HER2, HER1, AC 480 Hydrochloride, AC480 Hydrochloride, AC-480 Hydrochloride, BMS599626 Hydrochloride, BMS-599626 Hydrochloride, BMS 599626 Hydrochloride

Compound Identifiers

PubChem CID

46930994