BMS-582949 hydrochloride

SKU: orb1304180

Description

BMS-582949 hydrochloride is a potent and selective p38α mitogen-activated protein kinase (MAPK) inhibitor with an IC50 of 13 nM. This small molecule is a valuable research tool for investigating p38α signaling in inflammatory and autoimmune disease models, both in cellular and animal studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 912806-16-7
• MW: 442.95
• Purity: 97.57%
• Formula: C₂₂H₂₇ClN₆O₂
• SMILES: Cl.CCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NC3CC3)c2c1C
• Target: Autophagy,p38 MAPK
• Solubility: DMSO:50 mg/mL (112.88 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.64 mM)

Bioactivity

• Target IC50:
  p38α MAPK:13 nM|TNF-α:50 nM (in cells)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, BMS 582949, BMS 582949 hydrochloride, BMS 582949 Hydrochloride, BMS582949, BMS-582949, BMS-582949 HCl, BMS582949 Hydrochloride, BMS582949 hydrochloride, BMS-582949 Hydrochloride, Inhibitor, inhibit, p38 MAPK, p38MAPK, p38α

Compound Identifiers

PubChem CID

11848302