BMS-303141

SKU: orb1305652

Description

BMS-303141

Research Area

Cell Biology

Key Properties

• CAS Number: 943962-47-8
• MW: 424.30
• Purity: >98%
• Formula: C₁₉H₁₅Cl₂NO₄S
• SMILES: COc1ccc(cc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1O)-c1ccccc1
• Target: ATP Citrate Lyase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml with warming)

Bioactivity

• Target IC50:
  ACL:0.13 μM
• In Vivo:
  Chronic oral administration of BMS-303141 to mice on a high-fat diet reduces plasma cholesterol and triglycerides by approximately 20-30% and fasting plasma glucose by 30-50%. Continued treatment with BMS-303141 gradually inhibits weight gain and decreases adiposity without affecting food consumption. BMS-303141 displays an oral bioavailability of 55% and a relatively brief half-life of 2.1 hours.
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• In Vitro:
  BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM in HepG2 cells. BMS-303141 shows no cytotoxicity up to 50 lM under a cell-based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ACLYi

Compound Identifiers

PubChem CID

16747776