BMS-195270

SKU: orb1698107

Description

BMS-195270 is a tissue-selective small molecule inhibitor that reduces rat bladder muscle tone and spontaneous contractions. It effectively suppresses Carbachol-induced contractions and calcium influx in isolated tissue strips, making it a useful research tool for studying bladder physiology and overactive bladder mechanisms in vitro.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 202822-23-9
• MW: 355.7
• Purity: 98.70% (May vary between batches)
• Formula: C₁₅H₉ClF₃N₃O₂
• SMILES: O=C1NC(=NN1C2=CC(Cl)=CC=C2O)C=3C=CC=CC3C(F)(F)F
• Target: Calcium Channel,Others
• Solubility: DMSO:100 mg/mL (281.14 mM)

Bioactivity

• In Vitro:
  BMS-195270 inhibited the response of HEK293 cells to the muscarinic agonist carbachol (the EC50 was 2 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Calcium Channel, BMS195270, BMS-195270, BMS 195270, CalciumChannel, CHEMBL 13637, CHEMBL13637, CHEMBL-13637, SCHEMBL 5754043, SCHEMBL5754043, SCHEMBL-5754043, UNII-20UM0T170J

Compound Identifiers

PubChem CID

135564559