BMS-191011

SKU: orb1220368

Description

BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.

Key Properties

• CAS Number: 202821-81-6
• MW: 370.71
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₀ClF₃N₂O₃
• SMILES: O=c1oc(-c2ccc(C(F)(F)F)cc2)nn1Cc1cc(Cl)ccc1O
• Target: Potassium Channel
• Solubility: DMSO:125 mg/mL (337.19 mM)

Bioactivity

• In Vivo:
  BMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels In vivo. Animal model: Male Wistar rats (8-to 10-week-old) treated with Tetrodotoxin (50 μg/kg, intravenously (i. v.)). Dosage: 10-100 μg/kg. Administration: Intravenous injection; 10-100 μg/kg; once. Result: Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.
• In Vitro:
  BMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells. Cell Viability Assay Cell line: IGR39 and Panc-1 cells. Concentration: 20 or 40 μM. Incubation time: Result: Activated BK channels in less than 50% IGR39 cells and led to less than two-fold potentiation in Panc-1 cells. Promoted the activation of a voltage-independent K+ conductance at negative voltages.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS-A

Quick Database Links

Gene Symbol

Potassium Channel