BMS-135

SKU: orb3175040

Description

BMS-135 is a potent and selective ATP-competitive inhibitor of casein kinase 2 (CK2), with IC50 values of 0.8 nM for CK2α and 0.3 nM for CK2α' isoforms. It mimics the structure of ATP, binding to the active site of CK2 and inhibiting its serine/threonine phosphorylating activity. BMS-135 effectively inhibits cell proliferation and demonstrates antitumor properties, making it useful for research in colon cancer.

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1541248-36-5
• MW: 510.94
• Formula: C₂₂H₂₃ClN₁₀O₃
• SMILES: N(CC)C=1C=2N(C(C#N)=CN2)N=C(NC3=C(Cl)C(=CC(C#N)=C3)N4C[C@@H](O)[C@H](NC(OC)=O)CC4)N1
• Target: Casein Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Casein Kinase