BMS-1166-N-piperidine-COOH

SKU: orb1690829

Description

BMS-1166-N-piperidine-COOH is a chemical moiety derived from the potent PD-1/PD-L1 inhibitor BMS-1166 (IC50 = 1.4 nM). It serves as a key component in constructing PROTAC molecules, such as PROTAC PD-1/PD-L1 degrader-1, designed to target and degrade PD-1/PD-L1 proteins for immune-oncology research. This application is explored in both cellular and preclinical models to reactivate T-cell function.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2447066-00-2
• MW: 639.15
• Formula: C₃₇H₃₅ClN₂O₆
• SMILES: Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
• Target: Others,Ligands for Target Protein for PROTAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118434619