BMS-1001 hydrochloride

SKU: orb1309920

Description

BMS-1001 hydrochloride

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2113650-04-5
• MW: 631.11
• Purity: 99.57% (May vary between batches)
• Formula: C₃₅H₃₅ClN₂O₇
• SMILES: Cl.Cc1cc(CN[C@H](CO)C(O)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1
• Target: PD-1/PD-L1
• Solubility: DMSO:11.5 mg/mL (18.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.58 mM)

Bioactivity

• In Vitro:
  BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. It presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS1001, BMS-1001, BMS1001 Hydrochloride, BMS1001 hydrochloride, BMS-1001 Hydrochloride, BMS 1001, BMS 1001 hydrochloride, BMS 1001 Hydrochloride, checkpoint, PD1, PD-1/PD-L1, PD1/PDL1, PD-1, Inhibitor, low, inhibit, immune, ICB, PDL1, PD-L1, PD-L1/PD-1, toxicity

Compound Identifiers

PubChem CID

145925650