BML-278

SKU: orb1905834

Description

BML-278 is a SIRT1 activator (EC150 ~1 µM) that modulates histone and tubulin acetylation, impacting epigenetic regulation and cell morphology. It is used in research on cellular senescence, cell cycle arrest, and early embryonic development, with applications in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Neuroscience

Key Properties

• CAS Number: 120533-76-8
• MW: 391.47
• Purity: >98%
• Formula: C₂₄H₂₅NO₄
• SMILES: CCOC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccccc1)C(=O)OCC
• Target: Protein deacetylase
• Solubility: Soluble in DMSO (up to 5 mg/ml).

Bioactivity

• Target IC50:
  SIRT1:1 μM(EC50)

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BML278, BML-278, BML 278, HistoneMethyltransferase, Histone Methyltransferase, SIRT1

Compound Identifiers

PubChem CID

10620479