BML-278

SKU: orb1905834

Description

BML-278 is a SIRT1 activator with an EC150 of 1 μM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 120533-76-8
• MW: 391.46
• Purity: 99.98%
• Formula: C₂₄H₂₅NO₄
• SMILES: CCOC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccccc1)C(=O)OCC
• Target: Sirtuin,Histone Methyltransferase
• Solubility: DMSO:5.63 mg/mL (14.38 mM)

Bioactivity

• Target IC50:
  SIRT1:1 μM(EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BML278, BML-278, BML 278, HistoneMethyltransferase, Histone Methyltransferase, SIRT1

Compound Identifiers

PubChem CID

10620479