BML-190

SKU: orb1222417

Description

BML-190, also known as IMMA and LM-4131 or Indomethacin Morpholinylamide, is selective CB2 receptor agonist. The binding constant for the CB2 receptor is 435 nM compared to >20,000 nM for the cannabinoid receptor, CB1. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB(2) receptor and 16z44. BML-190 acts as inverse agonist at the human CB(2) receptor acting via G alpha(i/o) and G alpha(q) family-coupled pathways.

Key Properties

• CAS Number: 2854-32-2
• MW: 426.89
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₃ClN₂O₄
• SMILES: Cc1c(c2c(n1C(=O)c1ccc(cc1)Cl)ccc(c2)OC)CC(=O)N1CCOCC1
• Target: NF-κB
• Solubility: DMSO : 50 mg/mL 117.13 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BML-190 | BML 190 | BML190 | Indomethacin Morpholinylamide.

Quick Database Links

Gene Symbol

NF-κB