BM-PEG3

SKU: orb1307508

Description

BM-PEG3 (1,11-Bis-maleimidotetraethyleneglycol) is a heterobifunctional PEG linker widely used in constructing PROTACs and antibody-drug conjugates (ADCs). Its maleimide groups enable stable conjugation to thiol-containing biomolecules, facilitating the development of targeted degraders for in vitro and in vivo proteolysis research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 86099-06-1
• MW: 352.34
• Purity: 99.89% (May vary between batches)
• Formula: C₁₆H₂₀N₂O₇
• SMILES: C(COCCOCCOCCN1C(=O)C=CC1=O)N2C(=O)C=CC2=O
• Target: PROTAC Linker
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (2.84 mM);DMSO:10 mM

Bioactivity

• In Vitro:
  PROTACs, composed of two distinct ligands joined by a linker—one binding to an E3 ubiquitin ligase and the other to the target protein—use the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PROTAC Linker, PROTAC Linkers, PROTACLinker, 1,11-Bis-maleimidotetraethyleneglycol, BM PEG3, BMPEG3, BM-PEG3, BM-PEG-3, Inhibitor, inhibit, PEGs

Compound Identifiers

PubChem CID

3331999